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Additionally, gay males may regard oral sex as a way of maintaining their virginities, with penile-anal penetration defined as resulting in virginity loss, while other gay males may define oral sex as their main form of sexual activity.For conception to take place, sperm from the penis must enter the uterus and fallopian tubes and fertilize the female's egg.The study concludes that people who had one to five oral sex partners in their lifetime had approximately a doubled risk of throat cancer compared with those who never engaged in this activity and those with more than five oral sex partners had a 250 percent increased risk.Fellatio may reduce the risk of miscarriages by inducing immunological tolerance in the woman by exposure to the proteins in her partner's semen, a process known as paternal tolerance.Because of the aforementioned factors, medical sources advise the use of condoms or other effective barrier methods when performing or receiving oral sex with a partner whose STI status is unknown.Links have been reported between oral sex and oral cancer with human papillomavirus (HPV)-infected people.

Facesitting is a form of oral sex in which the receiver sits on the giver's face and pushes into it with his or her genitals.

While any exposure to a partner's semen appears to decrease a woman's chances for the various immunological disorders that can occur during pregnancy, immunological tolerance could be most quickly established through the oral introduction and gastrointestinal absorption of semen.

Recognizing that some of the studies potentially included the presence of confounding factors, such as the possibility that women who regularly perform fellatio and swallow semen also engage in more frequent intercourse, the researchers also noted that, either way, "the data still overwhelmingly supports the main theory" behind all their studies—that repeated exposure to semen establishes the maternal immunological tolerance necessary for a safe and successful pregnancy.

Autofellatio is a possible but rare variant; autocunnilingus may also be possible for women with extremely flexible spines.

An act of group sex restricted to one woman giving oral sex to several men is referred to as a gangsuck, blowbang or lineup, all derivatives of the slang term gang bang for group sex. Oral sex is commonly used as a means of preserving virginity, especially among heterosexual pairings; this is sometimes termed technical virginity (which additionally includes anal sex, mutual masturbation and other non-penetrative sex acts, but excludes penile-vaginal sex).

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